LACTOSE MONOHDRATE PHARMALACT PFEISINGER

Lactose: A Key Player in Pharmaceutical and Food Industries 

Lactose, often recognized for its versatility, holds an indispensable role in both the pharmaceutical and food industries. Its unique properties make it a reliable excipient in the formulation of oral solid dosage forms such as tablets, capsules, and sachets. Beyond its function in food, lactose’s significance in pharmaceuticals cannot be overstated, particularly in ensuring the efficacy and safety of medications. 

Lactose’s Role in the Pharmaceutical Industry 

In pharmaceutical manufacturing, lactose is not just a passive ingredient but an active participant in various functions. It serves as a filler, binder, diluent, disintegrant, and flow agent, which are all essential for ensuring that active pharmaceutical ingredients (APIs) are released efficiently in the body. The quality of lactose directly impacts the compaction, flow, and uniformity of the product, making it vital for the manufacturing process. 

The Role of Lactose in API Release 

Lactose plays a crucial role in controlling the release rate of active pharmaceutical ingredients (APIs). The flowability and compaction properties of lactose directly influence the uniformity of the dosage form, ensuring the effective release of the API in the body. 

Lactose Forms in Pharmaceutical Manufacturing 

Lactose comes in several forms, each suited for specific pharmaceutical applications. Here’s an overview of the different types: 

  • Milled and Sieved Lactose: Extensively used in wet granulation, this form is especially valuable for low-dose formulations. Its excellent flow and compaction properties make it ideal for ensuring uniformity in tablet production. Lactose sieved to 200 mesh is the most common choice for oral solid dose (OSD) production. 
  • Spray-Dried Lactose: Known for its porous structure, spray-dried lactose is a go-to for direct compression. It enhances the compactability and flow of the mixture, improving the hardness of tablets and ensuring uniform dispersion of the API. 
  • Granulated Lactose: This form is created by mixing lactose with water or a lactose solution, forming porous agglomerates. Its superb flow properties and rapid disintegration make it a preferred choice for direct compression. 
  • Anhydrous Lactose: With less than 0.5% water content, anhydrous lactose is perfect for dry granulation processes. Its low hygroscopicity also makes it an excellent choice for moisture-sensitive APIs, preventing degradation and ensuring long-term stability. 

Lactose’s Impact on Tablet Dissolution 

The dissolution rate of a tablet is crucial for its effectiveness in delivering the intended dose of the API. Lactose significantly influences this process, with different forms of lactose impacting the speed and efficiency of dissolution. Granulated lactose, for instance, disintegrates quickly, ensuring rapid release of the API. In contrast, anhydrous lactose, due to its compact structure, results in slower dissolution, which can be beneficial for controlled-release formulations. 

 

PFEISINGER Lactose Products: Precision and Quality 

PFEISINGER GmbH, a leading supplier of high-quality lactose, offers a variety of lactose products designed to meet the pharmaceutical industry’s stringent demands under the brand name of PHARMALACT. These products stand out for their exceptional properties that enhance formulation processes: 

 

PHARMALACT® 200M 

A finely milled α-lactose monohydrate, this product is ideal for both pharmaceutical and food applications. It offers superior compaction and blending properties, making it a go-to choice for a wide range of formulations. 

PHARMALACT 200 M LACTOSE MONOHYDRATE 

PHARMALACT® 80M 

A coarser α-lactose monohydrate, PHARMALACT® 80M excels in providing excellent flowability. It is particularly well-suited for capsules, sachets, and dry mixes. 

PHARMALACT 80 M LACTOSE MONOHYDRATE 80 MESH

 PHARMALACT® 21 AN 

This anhydrous lactose is renowned for its mechanical stability and versatility, ensuring precise dosing and product stability in both pharmaceutical and food applications.  

PHARMALACT 21 AN LACTOSE ANHYDROUS  

PFEISINGER’s lactose products provide pharmaceutical manufacturers with the consistency and quality they need to create effective, reliable medications. The company’s commitment to precision is evident in the formulation of each product, ensuring that they meet the highest standards. 

 

Wrapping Up 

Lactose, particularly when sourced from trusted manufacturers like PFEISINGER, plays a crucial role in the pharmaceutical and food industries. Whether it’s enhancing tablet compaction, improving flow properties, or ensuring controlled release, lactose’s versatility is unmatched. From granulated to anhydrous forms, each type of lactose serves a distinct purpose in ensuring the quality and efficacy of pharmaceutical products. As a supplier of premium lactose products, PFEISINGER continues to support both pharmaceutical and food industries by providing high-quality excipients that drive innovation and efficiency in manufacturing processes. 

Lactose isn’t just an ingredient; it’s a cornerstone in the creation of safe, effective, and reliable pharmaceutical and food products.